With a varicocele, what happens to dihydrotestosterone levels over time?

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Get ready for the Pediatrics Adolescent Exam with comprehensive flashcards and multiple-choice questions. Each question includes hints and explanations to aid your learning. Prepare for success on your exam!

Multiple Choice

With a varicocele, what happens to dihydrotestosterone levels over time?

Explanation:
Varicocele causes testicular stress from higher temperature and venous pooling, which over time impairs Leydig cell function and reduces testosterone production. Dihydrotestosterone (DHT) is made from testosterone via the enzyme 5-alpha-reductase in the tissues, including the testis. If testosterone levels fall because Leydig cells are compromised, the substrate for conversion to DHT decreases, so DHT levels decline over time. Therefore, the best answer is that DHT levels decrease.

Varicocele causes testicular stress from higher temperature and venous pooling, which over time impairs Leydig cell function and reduces testosterone production. Dihydrotestosterone (DHT) is made from testosterone via the enzyme 5-alpha-reductase in the tissues, including the testis. If testosterone levels fall because Leydig cells are compromised, the substrate for conversion to DHT decreases, so DHT levels decline over time. Therefore, the best answer is that DHT levels decrease.

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