Which GnRH agonist is used to treat endometriosis?

Which GnRH agonist is used to treat endometriosis?

• A. Leuprolide
• B. Zidovudine
• C. Misoprostol
• D. Mifepristone

Answer: (A)

Endometriosis is driven by estrogen, so reducing ovarian estrogen production helps shrink implants and relieve pain. A GnRH agonist like Leuprolide works by initially stimulating, then down-regulating the pituitary GnRH receptors, which lowers LH and FSH and dramatically decreases estrogen from the ovaries. This creates a reversible, chemically induced menopause-like state that diminishes endometrial tissue growth and symptoms. Leuprolide is commonly given as depot injections for several months and is often used with add-back therapy to lessen bone loss and vasomotor side effects. The other drugs listed aren’t GnRH agonists. Zidovudine is an HIV medication, Misoprostol is a prostaglandin used to induce labor or terminate pregnancy, and Mifepristone blocks progesterone receptors for abortion.

Endometriosis is driven by estrogen, so reducing ovarian estrogen production helps shrink implants and relieve pain. A GnRH agonist like Leuprolide works by initially stimulating, then down-regulating the pituitary GnRH receptors, which lowers LH and FSH and dramatically decreases estrogen from the ovaries. This creates a reversible, chemically induced menopause-like state that diminishes endometrial tissue growth and symptoms. Leuprolide is commonly given as depot injections for several months and is often used with add-back therapy to lessen bone loss and vasomotor side effects.

The other drugs listed aren’t GnRH agonists. Zidovudine is an HIV medication, Misoprostol is a prostaglandin used to induce labor or terminate pregnancy, and Mifepristone blocks progesterone receptors for abortion.